Alkyne dimerization represents a pivotal reaction in organic synthesis whereby two terminal alkynes combine to yield 1,3-enynes – molecules that constitute key building blocks for natural products, ...

Researchers have discovered a biosynthetic pathway that makes amino acids containing terminal alkynes. Because such functional groups are rare in natural products, they provide a handle for chemistry ...

In 2001, chemists K. Barry Sharpless, Hartmuth C. Kolb, and M. G. Finn introduced click chemistry, a concept in which organic ...

Middle molecules with a molecular weight of more than 1,000 are difficult to synthesize due to multiple steps and time-consuming nature, demanding the development of a new approach that can overcome ...

Kevin Shea focuses on organic chemistry. His lab uses organic synthesis to investigate new methods for carbon­-carbon bond formation and to develop syntheses of biologically active molecules.