SMN deficiency, primarily due to mutations in SMN1, results in widespread splicing defects, especially in spinal motor neurons, and is one cause of spinal muscular atrophy.

The SMN protein is found throughout the body, with highest levels in the spinal cord. This protein is one of a group of proteins called the SMN complex, which is important for the maintenance …

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Apr 22, 2025 · The Sensory-Motor Neuroscience Study Section (SMN) reviews applications on the anatomical and functional neurobiology of motor, sensorimotor, vestibular, and …

Jun 23, 2025 · Survival of Motor Neuron (SMN) is a protein found throughout the body that is essential for the health and function of the nervous system. It is particularly important for motor …

Spinal muscular atrophy (SMA) types 1 through 4 all result from a single known cause — a deficiency of a protein called SMN, which stands for " survival of motor neuron." Deficiency of …

SMN, or Survival of Motor Neuron, plays a significant role in the functionality and survival of motor neurons, which are critical for voluntary muscle movements.

Together with Gemin proteins, SMN forms the SMN complex, which orchestrates the stepwise assembly of snRNPs by binding Sm proteins and transferring them as a heptameric ring onto …

Learn about the biology, genetics, and causes of SMA, and how the SMN1 gene, SMN2 gene, and SMN protein affect SMA disease.

Dec 20, 2023 · Learn about the Smn gene, its role in spinal muscular atrophy (SMA), and current research and treatments.